Collingwood's gritty win in the west over Fremantle has come at significant cost, with midfielder Daniel Wells and forward Jamie Elliott failing to play out the game.

Wells, who missed the first four matches of the season with ongoing calf problems, pulled up lame late in the third quarter when trying to chase an opponent.

He immediately came from the field and played no further part in the match, and coach Nathan Buckley said the injury was to his opposite calf than the leg that troubled him earlier this year.

"Wellsy's strained a calf, so we'll see how that settles," Buckley said post-match.

"He's been around a long time, he loves playing footy, so he's going to be disappointed to miss some more."

The Pies were dealt another blow early in the final term when Elliott, who had kicked three vital third-quarter goals, suffered a left ankle injury and was helped from the field by two trainers. 

Elliott was assessed on the boundary and tested the injury on the sidelines, before returning to the bench.

He failed to return to the field and left the ground on crutches, and Buckley was unclear how long the star forward might be sidelined.

"Jamie's re-injured the ankle that he did earlier in the year," Buckley said.

"I'm not a doctor, I'll wait for them (for a prognosis).

The star duo aren't the only injury concerns ahead of the Magpies' Queen's Birthday clash with Melbourne in eight days' time.

Tyson Goldsack also looks in serious doubt after courageously playing out the game despite injuring his right shoulder.

Goldsack was severely limited in the use of his right arm but played a vital role deep in the forward line, halving a contest that led to Ben Crocker's late goal that sealed the game.

"His aerial (work) has been really strong for us and when you can only put one arm in the air it was pretty evident that might become costly, so we put him forward of the ball," Buckley said.

"That was a gutty effort by him to fight through that.

"Apparently there's some damage to the scapula, so we'll have to wait for the dust to settle and see how that pans out."

Meanwhile, Levi Greenwood laboured through the game with a suspected corked quad.