Steele Sidebottom, Dayne Beams, Leigh Brown and Anthony Corrie could make their Magpie debut on Saturday night.
Ben Reid and Simon Prestigiacomo have successfully recovered from injuries sustained last season and are named in the squad.
2008 Joseph Wren Trophy winner (best VFL player), Brent Macaffer, was elevated to the senior list at the end of last season and could see some playing time against West Coast.
The squad includes eight on the bench and three emergencies.
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The team list will be finalised 90 minutes before the start of the game.
Collingwood's squad:
1. Leon Davis
4. Alan Didak
5. Nick Maxwell
8. Harry O’Brien
9. Jack Anthony
10. Scott Pendlebury
11. Shane O’Bree
12. Shannon Cox
13. Dale Thomas
14. Anthony Corrie
15. Leigh Brown
16. Nathan Brown
17. Dayne Beams
18. Martin Clarke
19. Cameron Wood
20. Ben Reid
21. Sharrod Wellingham
22. Steele Sidebottom
24. Tarkyn Lockyer
25. Josh Fraser
26. Ben Johnson
28. Danny Stanley
29. Ryan Cook
30. Brent Macaffer
31. Chris Dawes
32. Travis Cloke
35. Simon Prestigiacomo
36. Dane Swan
39. Heath Shaw
West Coast's squad:
4. Daniel Kerr
6. Mark Nicoski
7. Chad Fletcher
11. Matt Priddis
13. Chris Masten
14. Mark Seaby
15. Tom Swift
16. Eric Mackenzie
17. Josh Kennedy
19. Tim Houlihan
20. Dean Cox
21. Quinten Lynch
23. Darren Glass
25. Shannon Hurn
27. Ben McKinley
30. Matt Spangher
31. Will Schofield
32. Andrew Embley
34. Tony Notte
35. Pat McGinnity
38. Brett Jones
40. Will Sullivan
41. Brent Staker
42. Beau Wilkes
43. Ashley Arrowsmith
45. Ryan Davis
46. Liam Bedford
47. Lewis Stevenson
48. Adam Cockie
