Collingwood will look to defend its preseason premiership when it takes on Greater Western Sydney Giants and the Western Bulldogs on Saturday night in the opening round of the NAB Cup.

Click here to view the Collingwood fixture.

The AFL has sent Nathan Buckley and his team to the Giants' home base at Blacktown International Sportspark on Saturday, February 18.

It looks to be an enthralling coaching match up with Buckley versus Kevin Sheedy and new senior coach Brendan McCartney.

The Magpies are the defending NAB Cup premiers, beating Essendon by 22 points in last year's Grand Final.

The 2012 NAB Cup will begin the previous evening at Etihad Stadium, with Hawthorn, North Melbourne and Richmond to meet each other.

On the Sunday, Essendon will travel to Perth to meet both West Coast and Fremantle.

The second part of the opening round features Geelong, St Kilda and the Sydney Swans on the Friday night (February 24) at Etihad Stadium, Gold Coast, the Brisbane Lions and Melbourne at Metricon Stadium on the Saturday night and will finish the following afternoon with Port Adelaide, Adelaide and Carlton at AAMI Stadium.

As part of the new-look competition, the NAB Regional Challenge disappears and the matches over the following fortnight - to be staged at both regular AFL venues and select regional centres, will also count in the NAB Cup standings.

Unlike the opening round-robin matches, again to be played over two 20-minute halves, all matches in the second and third rounds will be full-scale, four-quarter affairs.

The regional centres to feature games include Wangaratta (Essendon-St Kilda, March 3), Castle Hill (Sydney Swans-North Melbourne, March 3), Mandurah (West Coast-Port Adelaide, March 3), Alice Springs (Adelaide-Brisbane Lions, March 3), Albury (Greater Western Sydney-Gold Coast, March 10), Victor Harbour (Port Adelaide-Fremantle, March 10) and North Ballarat (North Melbourne-Western Bulldogs, March 11).

All matches will count equally with four points for a win and percentage also being taken into account. The two best-performed teams over the three rounds (two shortened and two full games) will play off in the NAB Cup Grand Final on March 17.

The 16 clubs who don't make the Grand Final will play one last NAB Cup match at various metropolitan locations across Australia on the weekend of March 16-18, a fortnight before most clubs will start their 2012 home and away seasons.

All first round NAB Cup matches will be televised exclusively live by Fox Sports, while 11 matches over the next two weeks will be also shown exclusively on Fox Sports.

The Grand Final will be shown live on Seven and Fox Sports as part of the League's new broadcasting agreement. In addition, one match per round will be broadcast on Telstra T-Box services, while all matches shown by Fox Sports will be broadcast on Telstra mobile.