Levi Greenwood is the headline inclusion in Collingwood's squad for Sunday's big clash with Essendon at the MCG.
Greenwood missed the win over Gold Coast on Saturday night after suffering concussion during the previous round's victory over Carlton.
Callum Brown, who was best on ground in the VFL Magpies' loss to Williamstown last weekend, has also come into the 26-man squad as have Sam Murray, Adam Oxley and Rupert Wills.
At this stage, Lynden Dunn is the only player to go out the team that defeated Gold Coast in round 15.
Dunn has been ruled out for the rest of the season due to a serious knee injury that will require a reconstruction.
Brody Mihocek has been named in Dunn's usual position of full-back.
Pies coach Nathan Buckley stated in his weekly press conference on Thursday that Mihocek, who arrived at Collingwood as a defender but earned his AFL debut after impressing as a forward in the VFL, was likely to spend a lot of time in the backline in the coming weeks.
Collingwood's 22-man team will be finalised at 5pm on Friday.
AFL Round 16
Sunday, July 8
MCG, 3.20pm
VIDEO | 949 days later, Brayden Sier debuted - https://t.co/x27fJWkkcf Brayden, his parents + girlfriend reflect on his journey from draft day to his debut #FOREVER pic.twitter.com/17jvM36vPy
— Collingwood FC (@CollingwoodFC) July 4, 2018